Cisplatin crosslink
WebCisplatin cross-links DNA and can consequently trigger apoptosis ( Sorenson & Eastman, 1988 ). Cisplatin can also enhance the activity of HSP90 inhibitors. When HSP90 in … WebSep 24, 2024 · Cisplatin ( cis -diamminedichloroplatinum II, [Pt (NH 3) 2 Cl 2 ]), and related platinum compounds such as oxaliplatin (C 8 H 14 N 2 O 4 Pt), are drugs used to treat a variety of solid tumors including breast, ovarian, head and neck, testicular, bladder, lung, brain, and esophageal cancers. 75–77 Platinum-based drugs bind to DNA, forming …
Cisplatin crosslink
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Web• Introduction 1. Features of inorganic drugs 2. Approaches in Drug Discovery • Anticancer metal complexes– cisplatin • Some other inorganic drugs 1,2-Intrastrand Cross-Link 1,2-Interstrand Cross-Link 1,2-链内交联 1,2-链间交联 √ STRUCTURAL CHANGES IN DNA: 引起DNA解旋和弯曲 B-DNA 1,2-Intrastrand Crosslink 1,2-Interstrand ... WebMar 5, 2008 · The cis- {Pt (NH3)2}2+ 1,2-d (GpG) intrastrand cross-link is the DNA lesion most commonly encountered following cisplatin treatment. We therefore assembled two …
WebOct 21, 2024 · DNA alkylating agents generally kill tumor cells by covalently binding with DNA to form interstrand or intrastrand cross-links. However, in the case of cisplatin, only a few DNA adducts (<1%) are h... WebApr 14, 2024 · Recently Concluded Data & Programmatic Insider Summit March 22 - 25, 2024, Scottsdale Digital OOH Insider Summit February 19 - 22, 2024, La Jolla
WebCisplatin, cis-[Pt(Cl 2 (NH 3) 2], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc … WebFeb 28, 2007 · For instance, cisplatin has been reported to cross-link chromosomal proteins, including histones or cytokeratins, to DNA (8, 9). Interestingly, DPCLs have been shown to play an important role in cytotoxicity within the clinical dosage range of cisplatin ( 10 ), but frequency of these ternary complexes depends on the cell type ( 11 ) and time of ...
WebMar 28, 2024 · The mechanism of action of cisplatin has been associated with ability to crosslink with the urine bases on the DNA to form DNA adducts, preventing repair of the DNA leading to DNA damage and...
WebDec 21, 2000 · We employ retro models, cis-PtA2G2 (A2 = a diamine, G = guanine derivative), to assess the cross-linked head-to-head (HH) form of the cisplatin−DNA d(GpG) adduct widely postulated to be responsible for the anticancer activity. Retro models are designed to have minimal dynamic motion to overcome problems recognized in models … bk services thierhauptenWebJul 6, 2016 · An abnormal differentiation state is common in BRCA1-deficient mammary epithelial cells, but the underlying mechanism is unclear. Here, we report a convergence between DNA repair and normal, cultured human mammary epithelial (HME) cell differentiation. Surprisingly, depleting BRCA1 or FANCD2 (Fancon … bks fachhandelWebCisplatin is a widely used chemotherapy agent in the treatment of various forms of carcinomas and sarcomas. Its effectiveness in delaying negative outcome in cancer patients has been amply documented, and attributed primarily to its ability to crosslink DNA purine bases, thus interfering with DNA re … Cisplatin in cancer treatment bk-services gmbh kehldaughter of shivaWebFeb 1, 1997 · Using cell extracts and circular duplex DNA, we compared nucleotide excision repair of uniquely placed 1,2-GG, 1,2-AG, and 1,3-GTG cisplatin-crosslinks, and a 2-acetylaminofluorene lesion. The 1,3 crosslink and the acetylaminofluorene lesion were repaired by normal cell extracts approximately 15-20 fold better than the 1,2 crosslinks. daughter of short formWebSep 16, 2004 · Single-stranded phiX174 DNA molecules were reacted with various molar ratios of cisplatin to DNA and under the conditions of platination we have used, GG and AG intrastrand crosslinks constitute ∼65% and 25% of the adducts, respectively, and GNG intrastrand crosslinks constitute ∼5–10%. bks fire door lockWebOct 5, 2014 · Cisplatin derivatives are used as the mainline treatment of ovarian cancer, despite their severe side effects and development of resistance. Cisplatin is used in … bksf twitter