Web大约 60 年前，Christian de Duve 首次使用了 "自噬" 一词，他观察到了大鼠肝脏溶酶体中的线粒体和其他细胞内结构的退化[1]。多年过去，“自噬” 依旧是国自然放在心尖尖上的宝贝。作为科研 “宠儿” 的线粒体自噬，不了解可就亏了~_线粒体自噬，怎能错过？ WebAs previously reported, FUNDC1 interacts with LC3B through its classical LIR - Y18xxL21, while the phosphorylation at Tyr18 by Src kinase remarkably reduces the FUNDC1-mediated mito- phagy. Under hypoxic stress, Tyr18 is dephosphorylated to promote the interaction between FUNDC1 and LC3B and mitophagy is triggered (Liu et al., 2012).

Mitochondrial autophagy: molecular mechanisms and implications …

WebDescription: Homo sapiens FUN14 domain containing 1 (FUNDC1), mRNA. (from RefSeq NM_173794) RefSeq Summary (NM_173794): This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known. [provided by RefSeq, Sep 2011]. Gencode Transcript: ENST00000378045.5 WebDec 13, 2024 · Our data suggested that FUNDC1 can be used as a prognostic biomarker in patients with cervical cancer, and may be a new therapeutic target to improve the … questions about the handmaid\u0027s tale

Phospho-FUNDC1 (Ser17) antibody Affinity Biosciences

WebReduced eNOS phosphorylation and VEGF expression, and upregulated ET-1 also suggested the endothelium dysfunction in FUNDC1 knockout mice (Fig. 1 I and J). Importantly, the EC-specific FUNDC1 deletion aggravated cardiac injury following MI/R as evidenced by reduced cardiac contractile function ( Fig. 1 K), enhanced CK-MB releases … WebJan 22, 2012 · Here we report that FUNDC1, an integral mitochondrial outer-membrane protein, is a receptor for hypoxia-induced mitophagy. FUNDC1 interacted with LC3 through its typical LC3-binding motif Y (18)xxL (21), and mutation of the LC3-interaction region impaired its interaction with LC3 and the subsequent induction of mitophagy. WebDec 17, 2024 · Under normoxic conditions, the activity of FUNDC1 is inhibited due to phosphorylation of FUNDC1 at Ser13 and Tyr18 by CK2 or Src, respectively. The phosphatase PGAM5 dephosphorylates FUNDC1 at Ser13, which is inhibited by Bcl-xL in normal conditions. In response to mitophagy stimuli, Bcl-xL is degraded and PGAM5 is … questions about the groom