Hepatocyte ferroptosis

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August undefined, 2024

Web6 aug. 2024 · Iron-dependent ferroptosis is characterized by a reduced glutathione level and increased lipid peroxidation. 14,16,53,54 A large number of studies have shown that … Web30 mrt. 2024 · Ferroptosis is a newly discovered iron-dependent, non-apoptotic, programmed cell death mode [10], caused mainly by iron deposition, of glutathione peroxidase (GPX4) inactivation, and polyunsaturated fatty acids accumulation, accompanied by massive lipid peroxides production [11].

Ferroptosis and Its Role in Chronic Diseases - MDPI

Web20 nov. 2024 · Hepatic stellate cells (HSCs) play a pivotal role in the progression of hepatic fibrosis by increasing the production and secretion of the extracellular … Web9 jul. 2024 · Third, strategy targeting a specific liver cell type using dedicated vectors seems highly desirable (hepatocyte versus HSC), since ferroptosis possesses a dual role in … swisstech convention center epfl

Ferroptosis is involved in alcohol-induced cell death

Web10 apr. 2024 · 3月20日，我校医学院2024级硕士研究生姚超作为第一作者、安徽理工大学医学院为第一单位，首次在口腔医学领域JCR1区期刊《Oral Disease》在线发表题为《Porphyromonas gingivalis triggers inflammation in hepatocyte depend on ferroptosis via activating the NF-κB signaling pathway》的论文，该文通讯作者为安徽理工大学兼聘硕士 … Web29 apr. 2024 · Hepatic ferroptosis has been found in the liver of animal models of alcoholic liver disease (ALD), nonalcoholic steatohepatitis, acetaminophen induced hepatotoxicity, … Web1 mrt. 2024 · Purpose Ferroptosis is reported to be involved in the chronic intermittent hypoxia (CIH)-related liver damage in vivo. Nuclear factor E2-related factor 2 (Nrf2) has … swiss tech cups

Ferroptosis contribute to hepatic stellate cell activation and liver ...

Cells Free Full-Text Ferroptosis: Shedding Light on Mechanisms …

WebHepatocyte ferroptosis Few studies have reported on the role of hepatocyte ferroptosis in the development of liver fibrosis. The evidence suggests that hepatocyte and HSCs … Web5 okt. 2024 · Ferroptosis was first identified in 2012 as a novel form of regulated cell death (RCD). It is characterized by excessive accumulation of intracellular lipid reactive oxygen species (ROS) and... swiss tech cutter asp60 12 sr94Web21 mrt. 2024 · Ferroptosis is a form of iron-dependent regulated cell death and has two major hallmarks, intracellular iron overload and redox system disorder. The activation of … swiss tech credit card wallet

"Web10 nov. 2024 · Ferroptosis is a novel form of programmed cell death caused by iron-dependent lipid peroxidation. Abnormal iron metabolism, lipid peroxidation, and accumulation of polyunsaturated fatty acid... " - Hepatocyte ferroptosis

Hepatocyte ferroptosis

Web17 aug. 2024 · Ferroptosis is an iron-dependent, ... Indeed, the knockout of Slc39a14 suppresses ferroptosis-related liver fibrosis in hepatocyte-specific trf knockout mice … Web1 jan. 2024 · In summary, our data demonstrated that hepatocyte NLRP3 over-activation leads to hepatocyte pyroptosis and secretion of inflammasome complexes into the …

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WebFerroptosis is characterized by excessive production of lipid peroxides mediated by iron catalysis and is distinct from apoptosis, necroptosis, and pyroptosis. Also, it occurs when intracellular glutathione peroxidase 4 (GPX4) is inhibited by a lowered GSH level [ 9 ]. WebLipid accumulation is exacerbated by lipid metabolism disorders, which contribute to the pathogenesis of anti-TB drug-induced hepatotoxicity [ 11 ]. Ferroptosis is a lipid-ROS- …

Web20 okt. 2024 · In general, hepatocyte ferroptosis can aggravate the progression of multiple liver diseases, while the ferroptosis of HSCs and HCC cells could repair the damage of …

Web27 jun. 2024 · Ferroptosis is a new type of programmed cell death with unique morphological, biochemical, ... ACSL4-dependent ferroptosis establishes a link between … Web18 jun. 2024 · Nonalcoholic steatohepatitis (NASH) is a metabolic liver disease that progresses from simple steatosis to the disease state of inflammation and fibrosis. …

Web30 mei 2024 · The mechanisms of liver disease are complex. Notably, ferroptosis, a new type of cell death driven by iron and lipid peroxidation, is considered to be the key …

Web8 apr. 2024 · Ferroptosis is mainly caused by iron-dependent lipid peroxidation. Free Fe 3+ forms a complex with extracellular transferrin, which binds to a TfR1 on the cell membrane and forms endosomes that ... swiss tech credit card toolWebTherefore, targeting ferroptosis might serve as a hepatoprotective strategy for ALD treatment. In a study by Zhou et al. (2024), ferroptosis was identified as a mechanism … swisstech convention center ecublensWeb20 nov. 2024 · Furthermore, we found that both isolated primary hepatocyte and HSCs undergo ferroptosis. Consistently, cirrhotic liver tissue of patients indicated glutathione … swiss tech crew neck sweatshirtWeb1 mrt. 2024 · Mechanistically, GLY-triggered hepatocyte ferroptosis was due to GSH depletion via diminishing the phosphorylation and nuclear translocation of Nrf2. In total, … swiss tech down coatWeb28 aug. 2024 · Objective: To explore the role and mechanism of haptoglobin (Hp) in hepatocyte ferroptosis. Methods: Thirteen 8-week-old C57BL/6J male mice were … swiss tech 3 in 1 system jacketWeb10 apr. 2024 · Background: Liver fibrosis and hepatocellular carcinogenesis secondary to liver fibrosis are serious liver diseases with no effective treatments. Mori fructus aqueous extracts (MFAEs) have served... swisstech cryptoWeb1 mrt. 2024 · Under normal physiological conditions, ferroptosis can remove damaged cells to sustain cellular balance, but ferroptosis can also stimulate the initiation and progress of diseases, such as cancer, neurodegenerative disorders, and diabetes ( David et al., 2024; Li et al., 2024; Vats et al., 2024; Yao et al., 2024 ). swisstech excursion backpack