WebSep 2, 2024 · Phosphatidylethanolamine-binding protein 4 (PEBP4) is a secreted protein involved in regulating many molecular pathways, whereas its roles in diseases including hepatic fibrosis remain undefined.... WebPEBP4 was first identified as a regulator of the MAPK pathway (5, 20). Wang et al have shown that PEBP4 interacts with Raf-1 and MEK1 and attenuates activation of MEK1. This …
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WebSummary of RNA expression and protein localization based on data generated within the Human Protein Atlas project. Main locationi. Main subcellular location (s) and reliability score (s) for the encoded protein (s) in human cells. The main location (s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity ... WebJul 8, 2024 · Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein with multiple biological functions. At present, studies on PEBP4 exist mainly in the field of tumors and rarely in inflammation. This study aimed to explore the potential roles and mechanisms of PEBP4 on lipopolysaccharide (LPS)/D-galactosamine (D-GalN) - induced ALI.
WebSep 15, 2012 · PEBP4 is expressed in the mammalian testis, heart, skeletal muscle, thyroid, liver, spinal cord, brain, adrenal gland and bone marrow, and other tissues . PEBP4 is mainly involved in the biosynthesis of the plasma membrane, neural development, spermatogenesis, apoptosis, and other physiological and pathological processes . Recent … WebFeb 1, 2007 · PEBP4 (phosphatidylethanolamine binding protein 4) 2007-02-01 Identity HGNC PEBP4 LOCATION 8p21.3 LOCUSID 157310 ALIAS CORK-1, CORK1, GWTM1933, …
Webeffects of PEBP4 on LSCC can be neglected in most cases of LSCC, where PEBP4 demonstrated decreased expression levels. However, in the case of PEBP4 overexpression, it may contribute to the progression of LSCC and lead to the develop - ment of drug resistance. Introduction Lung cancer is a leading cause of cancer-associated mortality WebFeb 5, 2024 · PEBP4 was associated with the development and invasion of gastric cancer cells through activation of the PI3K/Akt signaling pathway knockdown of PEBP4 inhibited hypoxia-induced epithelial-to-mesenchymal transition in prostate cancer cells. this study suggested that PEBP4 might promote the progression of pancreatic ductal adenocarcinoma
WebOct 17, 2015 · The PI3K/Akt/mTOR signaling axis may be a key molecular pathway via which PEBP4 promotes the proliferation and invasion of non-small cell lung cancer (NSCLC) …
WebHeart musclei. On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and … sun lounger new zealandWebOct 26, 2024 · Phosphatidylethanolamine-binding protein 4 (PEBP4), a member of the PEBP family, has been reported to play a pivotal role in tumor progression. However, its role in epithelial-to-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC) cells remains unclear. Here, we investigated the effects and underlying mechanism of PEBP4 in … sun lounger covers waterproofWebNov 12, 2011 · PEBP4 is expressed in the mammalian testis, heart, skeletal muscle, thyroid, liver, spinal cord, brain, adrenal gland, and bone marrow [ 14 ], and mainly participates in physiopathological processes such as membrane biosynthesis, neurodevelopment, spermatogenesis, and apoptosis [ 4 ]. sun lounge repairs brisbaneWebJan 20, 2024 · Interaction between whitefly PEBP4 and TYLCV CP suppresses phosphorylation of MAPK cascade, activating apoptosis. TYLCV CP liberates PEBP4 … sun lounger tescoWebThe phosphatidylethanolamine (PE)-b inding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and … sun lounger cushion covers ukWebDec 1, 2024 · PEBP4 is a ubiquitous and evolutionary conserved but scarcely studied protein that like the other PEBP family members (PEBP1-4), potentially binds … sun lounge chairsWeb(E): PEBP4 protein expression was tested by western blotting in the heart, liver, lungs, spleen, and kidneys of WT and CKO mice. Data are presented as mean ± SD values (n = 3). … sun lounger cushion water resistant